Cohort profile: The Australian Paediatric Exposure to Radiation Cohort (Aust-PERC)

J McBain-Miller; KJ Scurrah; Z Brady; JD Mathews

Journal article

Cohort profile: The Australian Paediatric Exposure to Radiation Cohort (Aust-PERC)

J McBain-Miller, KJ Scurrah, Z Brady, JD Mathews

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2022

DOI: 10.1371/journal.pone.0271918

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Abstract

Although the carcinogenic effects of high-dose radiation are well-established, the risks at low doses, such as from diagnostic X-rays, are less well understood. Children are susceptible to radiation induced cancers, and in the last decade, several cohort studies have reported increased cancer risks following computed tomography (CT) scans in childhood. However, cohort studies can be limited by insufficient follow-up, indication bias, reverse causation, or by lack of organ doses from CT scans or other exposures. Aust-PERC is a retrospective cohort designed to study the effects of low-dose medical radiation exposure, primarily from CT scans, in young Australians. The cohort was ascertained usi..

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University of Melbourne Researchers

Katrina Scurrah Author

John Mathews Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council (https://www.nhmrc.gov.au) awarded to JDM [grant numbers 509190, 1027368, and 1084197] The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.